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Arifuzzaman S, Das A, Kim SH, Yoon T, Lee YS, Jung KH, Chai YG. Selective inhibition of EZH2 by a small molecule inhibitor regulates microglial gene expression essential for inflammation. Biochem Pharmacol. 2017 Apr 19. pii: S0006-2952(17)30233-2. doi: 10.1016/j.bcp.2017.04.016. PMID: 28431938
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Das Amitabh, Arifuzzaman S, Yoon TH, Kim SH, Chai JC, Lee YS, Jung KH, Chai YG. RNA sequencing reveals resistance of TLR4 ligand-activated microglial cells to inflammation mediated by the selective jumonji H3K27 demethylase inhibitor. Scientific Reports, 2017 Jul. 27. 7:6554 doi:10.1038/s41598-017-06914-5.PMID: 28747667 (Co-first author)
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Das A, Arifuzzaman S, Kim SH, Lee YS, Jung KH, Chai YG. FTY720 (fingolimod) regulates key target genes essential for inflammation in microglial cells as defined by high-resolution mRNA sequencing. Neuropharmacology. 2017 Mar 31;119:1-14. doi: 10.1016/j.neuropharm.2017.03.034. PMID:28373076
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Das A, Kim SH, Arifuzzaman S, Yoon T, Chai JC, Lee YS, Park KS, Jung KH, Chai YG. Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia. J Neuroinflammation. 2016 Jul 11;13(1):182. doi: 10.1186/s12974-016-0644-1. PMID: 27400875.
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Das, Amitabh, Yang CS, Arifuzzaman S, Kim SJ, Kim SY, Jung KH, Lee YS, Chai YG. High-Resolution Mapping and Dynamics of the Transcriptome, Transcription Factors, and Transcription Co-Factor Networks in Classically and Alternatively Activated Macrophages. Front. Immunol., 18 January 2018 | https://doi.org/10.3389/fimmu.2018.00022
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Arifuzzaman S, Chai JC, Das A, Lee YS, Jung KH, Chai YG. Selected TLR7/8 agonist and type I interferon (IFN-α) cooperatively redefine the microglia transcriptome.
Journal of Neuroinflammation (under revision)